Nerve growth factor (NGF) is initially in a complex of 3 proteins – α-NGF, β-NGF, and γ-NGF when expressed. This form of NGF is also referred to as proNGF (NGF precursor). The γ subunit of this complex acts as a serine protease, and cleaves the N-terminal of the β subunit, thereby activating the protein into functional NGF. The term “Nerve Growth Factor” usually refers to the β subunit of the protein. NGF is a neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.
NGF appears to promote myelin repair. Hence NGF may be useful for the treatment of multiple sclerosis. NGF could also be involved in various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Dysregulation of NGF signaling has also been linked to Alzheimer’s disease.
β-NGF ELISA Kit, Human
$529.00
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human β-NGF. The Human β-NGF ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Weight | 1 lbs |
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Dimensions | 8 × 6 × 4 in |
Sensitivity | |
Standard Curve | 15.63 – 1000 pg/ml |
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