T-cell immunoglobulin and mucin domain 1 (TIM-1) also known as Kidney injury molecule 1 (KIM-1) and Hepatitis A virus cellular receptor 1 (HAVcr1) is a member of the TIM gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection. TIM-1 is preferentially expressed on Th2 cells and has been identified as a stimulatory molecule for T-cell activation. TIM-1 is also involved in allergic response, asthma, and transplant tolerance. In humans, TIM-1 serves as a cellular entry receptor for various viruses such as hepatitis A virus, dengue virus and ebola virus.