Oncostatin-M-specific receptor subunit beta, also known as OSMR, is a member of the type I cytokine receptor family. OSMR contains four fibronectin type-III domains and is expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor celllines.
This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Defects in OSMR are the cause of amyloidosis type 9 which is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition.