Matrix metalloproteinase-10 (MMP-10) also known as stromelysin-2 or transin-2 is an enzyme that in humans is encoded by the MMP10 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-10 has been linked to cancer stem cell vitality and metastasis.
This kit is designed to measure e pro form of recombinant human MMP-10 and the mature form of recombinant human MMP-10 by itself or when complexed to recombinant human TIMP-1.