LMAN2 (Lectin mannose-binding 2), also known as VIP36, is a protein that in humans is encoded by the LMAN2 gene. LMAN2 has been originally isolated from MDCK cells as a component of glycolipid-enriched detergent-insoluble complexes containing apical marker proteins. LMAN2 binds glycoproteins that retain the intact D1 mannosyl branch in the cis-Golgi network and recycles to the endoplasmic reticulum where, due to higher pH, it releases its cargos, thereby contributing to the quality control of glycoproteins. LMAN2 is an intracellular lectin that cycles between the endoplasmic reticulum and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoproteins. The interaction between recombinant soluble LMAN2 and BiP is dependent on divalent cations but not on ATP.