Description
Low-density lipoprotein (LDL) receptor (LDLR) is a mosaic protein of 839 amino acids which belongs to the LDLR gene family. It is a cell-surface receptor that recognizes the Apo B100, which is embedded in the outer phospholipid layer of LDL particles. The receptor also recognizes the Apo E protein found in chylomicron remnants and VLDL remnants.
LDLR mediates the endocytosis of cholesterol-rich LDL. LDLR complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells, but mainly in the liver which removes ~70% of LDL from the circulation. Hyperthyroidism may be associated with hypocholesterolaemia via upregulation of the LDLR, and hypothyroidism with the converse.
Only logged in customers who have purchased this product may leave a review.
Reviews
There are no reviews yet.