Fibroblast growth factor receptor 2 (FGFR2), also known as CD332, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. This protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Mutations are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes) and cancer.