DOPA Decarboxylase / DDC ELISA Kit, Human
$529.00
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human DDC. The Human DOPA Decarboxylase/DDC ELISA is for research use only. Not for diagnostic or therapeutic procedures.
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Description
DOPA decarboxylase (DDC), also known as aromatic-L-amino acid decarboxylase, is a 54 kDa lyase enzyme. It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3, 4 -dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan (5-HTP) to dopamine and serotonin, respectively. In normal dopamine and serotonin neurotransmitter synthesis, DDC is not the rate-limiting step in either reaction. However, DDC becomes the rate-limiting step of dopamine synthesis in patients treated with L-DOPA (such as in Parkinson’s Disease), and the rate-limiting step of serotonin synthesis in people treated with 5-HTP (such as in mild depression or dysthymia). DDC is inhibited by Carbidopa outside of the blood brain barrier to inhibit the premature conversion of L-DOPA to dopamine in the treatment of Parkinson’s. In humans, DDC is also the rate-limiting enzyme in the formation of trace amine neurotransmitters. Deficiency of DDC is associated with various symptoms as severe developmental delay, oculogyric crises and autonomic dysfunction.
Additional information
| Weight | 1 lbs |
|---|---|
| Dimensions | 8 × 6 × 4 in |
| Sensitivity | |
| Standard Curve | 468.75 – 30000 pg/ml |
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