CXCL13 / BLC / BCA-1 ELISA Kit, Human
$529.00
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human CXCL13. The Human CXCL13/BLC/BCA-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
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Description
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1) is expressed highly in the liver, spleen, lymph nodes, and gut of humans. It is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or Tfh cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.
Additional information
| Weight | 1 lbs |
|---|---|
| Dimensions | 8 × 6 × 4 in |
| Sensitivity | |
| Standard Curve | 31.25 – 2000 pg/ml |
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