C-X-C motif chemokine 11(CXCL11), also known as interferon-inducible T-cell alpha chemoattractant (I-TAC), is a small cytokine belonging to the CXC chemokine family. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.
CXCL11 elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3. CXCL11 is chemotactic for activated T cells. CXCL11 exhibits an angiostatic effect. It has been implicated in allergic contact dermatitis, atherosclerosis, mycosis fungoides (a type of T cell lymphoma), and immune-mediated disorders of the central nervous system such as multiple sclerosis.