Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. Angiopoietin-1 (ANG-1) encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa, can form dimers, trimers, and tetramers. It is critical for vessel maturation, adhesion, migration, and survival. Deregulation of angiopoietin and the tyrosine kinase pathway is common in blood-related diseases such as diabetes, malaria, sepsis, and pulmonary hypertension. This is demonstrated by an increased ratio of ANG-2 and ANG-1 in blood serum.