17

Mar

How insulin-producing cells show their age

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Markers of aging will help us understand how beta cells begin to fail in type 2 diabetes

[ScienceDaily®] Diabetes researchers have puzzled for decades about why insulin-producing beta cells in one pancreatic islet often look and behave quite differently than their counterparts in the same islet or in nearby islets. Using newly identified cellular markers of aging, Joslin Diabetes Center scientists now have shown that this diversity may be driven at least in part by differently aged beta cell populations within the pancreas. (4/5/2017)

Full Story:
https://www.sciencedaily.com/releases/2017/04/170405112023.htm

Journal Reference:
Aguayo-Mazzucato C, et al. β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metabolism, 2017; 25 (4): 898 DOI: 10.1016/j.cmet.2017.03.015

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