IL-20 ELISA Kit, Human
$529.00
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-20. The Human IL-20 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
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Description
Human interleukin 20 (IL-20) is a protein belonging to the IL-10 family of cytokines. It exhibits approximately 28% amino acid (aa) identity with IL-10 and 76% aa identity with mouse IL-20. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. In addition, IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyperproliferation, abnormal epidermal differentiation, and neonatal lethality.
Additional information
| Weight | 1 lbs |
|---|---|
| Dimensions | 8 × 6 × 4 in |
| Sensitivity | |
| Standard Curve | 46.88 – 3000 pg/ml |
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