Apolipoprotein E / Apo E ELISA Kit, Human
$529.00
This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human Apo E. The Human Apolipoprotein E /Apo E ELISA is for research use only. Not for diagnostic or therapeutic procedures.
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Description
Apolipoprotein E (Apo E) is a class of apolipoprotein found in the chylomicron and Intermediate-density lipoprotein that is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. In peripheral tissues, Apo E is primarily produced by the liver and macrophages, and mediates cholesterol metabolism in an isoform-dependent manner. In the central nervous system, Apo E is mainly produced by astrocytes, and transports cholesterol to neurons via Apo E receptors.
Apo E transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. In the field of immune regulation, a growing number of studies point to Apo E’s interaction with many immunological processes, including suppressing T cell proliferation, macrophage functioning regulation, lipid antigen presentation facilitation to natural killer T cell as well as modulation of inflammation and oxidation. The secretion of Apo E by monocytes is down regulated by inflammatory cytokines and upregulated by TGF-β. This protein is involved in Alzheimer’s disease and cardiovascular disease.
Additional information
| Weight | 1 lbs |
|---|---|
| Dimensions | 8 × 6 × 4 in |
| Sensitivity | |
| Standard Curve | 78.13 – 5000 pg/ml |
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